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Search Results for " intraocular pressure "

53

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T3174	Taprenepag CP-544326	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Taprenepag (CP-544326) 是一种有效的选择性前列腺素 E2 受体激动剂，EC50为 2.8 nM，可用于研究开角治疗高眼压和青光眼的试验。
T12670	(Rac)-MGV354 MGV354,外消旋MGV354	Others	Others
	(Rac)-MGV354 (MGV354) 是 MGV354 的外消旋体，MGV354 是可溶性鸟苷酸环化酶活化剂，在 GTM-3E 和 CHO 细胞中 EC50分别为 5 nM 和小于 0.5 nM。
T0142	Brinzolamide 布林佐胺,AL-4862	Carbonic Anhydrase	Metabolism
	Brinzolamide (AL-4862) 是一种碳酸酐酶(carbonic anhydrase)II 抑制剂(IC50:3.19 nM)。
T0106	Methazolamide L584601,醋甲唑胺,CL 8490	Carbonic Anhydrase	Metabolism
	Methazolamide (CL 8490) 是一种磺胺衍生物，用作碳酸酐酶 (carbonic anhydrase) 抑制剂，对人 carbonic anhydrase II 的 Ki=为 14 nM。它是降低眼压的药物，能够抑制由青光眼及其他眼病引起的眼压升高的作用。
T60924	Verosudil AR-12286	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Verosudil (AR-12286) 是一种高效的 Rho 激酶 (ROCK) 抑制剂，对 ROCK1 和 ROCK2 的 Ki 分别为 2 和 2 nM。AR-12286 可逆转类固醇诱导的小鼠眼内压，可通过增加眼房水通过小梁网流出来减缓眼压。
T6422	Brimonidine Tartrate AGN190342 tartrate,304 tartrate,酒石酸溴莫尼定,AGN190342 (tartrate),UK 14304 (tartrate),UK14304 tartrate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Brimonidine Tartrate (AGN190342 tartrate) 是一种 alpha2 Adrenergic Receptor (alpha2-AR) 受体激动剂。
T19870	Aceclidine 3-Acetoxyquinuclidine,1-azabicyclo[2.2.2]octan-3-yl acetate,NSC657843,3-quinuclidinyl acetate,NSC-657843,Glaucostat,NSC 657843,Quinuclidin-3-yl acetate	AChR	Neuroscience
	Aceclidine (1-azabicyclo[2.2.2]octan-3-yl acetate) 是M3 mAChR 的调节剂，可用于有关通过降低眼内压治疗青光眼的研究。
T10358	Netarsudil Dihydrochloride AR-13324 Dihydrochloride	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) 是 Rho 相关蛋白激酶 (ROCK) 和去甲肾上腺素转运蛋白 (NET) 的抑制剂，可有效降低眼压 (IOP)。
T21371	Apraclonidine hydrochloride Iopidine,ALO 2145,Apraclonidina,P-aminoclonidine,4-Aminoclonidine,Apraclonidine HCl,Apraclonidinum	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Apraclonidine hydrochloride (ALO 2145) 是一种 α2-肾上腺素能激动剂和弱的 α-1 肾上腺素能受体激动剂。 Apaclonidine hydrochloride 可降低人眼的眼内压，可用于青光眼治疗的研究。
T15719	Latanoprostene bunod LBN,NCX116	Others	Others
	Latanoprostene bunod (LBN) 是一氧化氮 (NO) 供体前列腺素 F2a 类似物，有用于开角型青光眼或高眼压 (OHT) 患者降低眼压 (IOP) 的局部眼科的研究潜力。
T22029	AL 34662	5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	AL 34662 是一种具有选择性和高效性的 5-HT2A 受体激动剂，对大鼠和人 5-HT2 受体的IC50 分别为 0.77 nM 和 1.5 nM。AL 34662 还是一种亲和力较低的 α-1D 肾上腺素能激动剂，EC50 值为 0.4 μM。AL 34662 可用于降低眼压。
T2403	Bromfenac sodium hydrate Bromfenac sodium,Bromfenac monosodium salt sesquihydrate,溴芬酸钠	COX	Immunology/Inflammation; Neuroscience
	Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) 是一种可口服的 COX 抑制剂，抑制 COX-1和COX-2的IC50值分别为 5.56 和 7.45 nM。它是一种溴化非甾体类抗炎药，有用于白内障的术后炎症和疼痛以及假晶状体囊状黄斑水肿的研究。
T25483	H-0106 Dihydrochloride H 0106 2HCl,H0106 2HCl,H0106 Dihydrochloride
	H-0106 Dihydrochloride is an inhibitor of ROCK that acts by applying strong intraocular pressure (IOP)-lowering effects into the eyes of monkeys.
T13955	Unoprostone	Others	Others
	Unoprostone is a prostaglandin F2α analogs (PGAs), and reduces intraocular pressure and is used topically for glaucoma or ocular hypertension.
T25482	H-0104 Dihydrochloride H0104 Dihydrochloride,H0104 2HCl,H 0104 Dihydrochloride,H 0104 2HCl,H-0104 2HCl
	H-0104 Dihydrochloride is an inhibitor of ROCK that acts by applying potent intraocular pressure (IOP)-lowering effects into the eyes of monkeys.
T10358L2	Netarsudil mesylate AR-13324 (mesylate)	Others	Others
	Netarsudil mesylate is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective in intraocular pressure (IOP) reduction.
T19682	Levobetaxolol (S)-(-)-Betaxolol,(S)-Betaxolol
	Levobetaxolol, also known as AL-1577A and Betaxon, is a cardioselective β-adrenergic receptor inhibitor. It has been demonstrated to reduce intraocular pressure in patients affected by ocular hypertension and primary open-angle glaucoma.
T11821	Latanoprost lactone diol	Others	Others
	Latanoprost lactone diol is an important intermediate compound in the synthesis of Latanoprost. Latanoprost, classified as a prostaglandin F2α analogue, functions as an agonist for the FP prostanoid receptor, resulting in a reduction in intraocular pressure (IOP).
T28126	Nabitan hydrochloride Benzopyranoperidine,A-40656,A40656,SP-106,A 40656,Nabutam
	Nabitan hydrochloride is a synthetic cannabinoid analog with antiemetic and analgesic effects. It may bind to and activate the CB1 and CB2 cannabinoid receptors. It also reduces intraocular pressure and may be useful in treating glaucoma.
T71120	AR-13503
	AR-13503, is an metabolite of Netarsudil (AR-11324), is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure.
T60807	Cannabicitran
	Cannabicitran 是一种可以降低家兔眼压的大麻素。
T37991	15-keto Prostaglandin F2α 15-keto Prostaglandin F2α,15-keto PGF2α	Endogenous Metabolite; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	15-keto Prostaglandin F2α 是 Prostaglandin F2α 的代谢物，可降低兔眼压。
T61216	Dichlorphenamide disodium
	Dichlorphenamide disodium is a specific, orally active carbonic anhydrase inhibitor. It effectively reduces intraocular pressure by impeding the secretion of aqueous humor. Notably, dichlorphenamide disodium holds potential for glaucoma research [1].
T38196	Prostaglandin F2α isopropyl ester Prostaglandin F2α isopropyl ester
	PGF2α isopropyl ester is an ester prodrug of PGF2α with enhanced lipid solubility. Due to better membrane penetration, PGF2α isopropyl ester is more suitable than PGF2α or PGF2α tromethamine salt for topical application in studies on intraocular pressure. The ester functionality is readily hydrolyzed in vivo to release the active compound PGF2α. When administered topically to the eyes of cynomolgus monkeys, a 5 μg dose reduces intraocular pressure by 68% after the fourth day of treatment.
T75155	Bamosiran
	Bamosiran 是一种靶向 β-肾上腺素受体2 (β-adrenergic receptor 2)的 siRNA，用于降低眼压
T38198	Prostaglandin F2α methyl ester
	Prostaglandin F2α methyl ester 是一种具有高脂溶性的 PGF2α 类似物，用用于维持低眼压。
T10357	AR-13324 analog mesylate	Others	Others
	AR-13324 analog mesylate is an inhibitor of Rho-kinase and a norepinephrine transporter and reduces intraocular pressure in normotensive monkey eyes.
T60848	Carbonic anhydrase inhibitor 3
	Carbonic anhydrase inhibitor 3 (compound 11g) 可降低青光眼兔的眼压，它是一种碳酸酐酶 II 的抑制剂，。
T61120	Carbonic anhydrase inhibitor 2
	Carbonic Anhydrase Inhibitor2 (compound 7c) 是一种针对 Carbonic Anhydrase II 抑制剂，有效降低青光眼兔眼压。
T37956	Tafluprost ethyl amide
	Tafluprost ethyl amide 是一种前列腺素衍生物。Tafluprost ethyl amide 能降低眼压 (IOP)，影响睫毛生长。Tafluprost ethyl amide 可用于抗青光眼眼药及化妆品。
T38194	Prostaglandin E3 PGE3
	Prostaglandin E3 (PGE3) is formed via the cyclooxygenase (COX) metabolism of eicosapentaenoic acid. [1] In human ocular tissue, it comprises 2.4% of the COX products formed. [1] When applied to the eyes of a rabbit, a 1 &#181g dose of PGE3 decreases intraocular pressure from 21 mmHg to about 17 mmHg.[2]
T36145	12(R)-HETE
	Biosynthesis of 12(R)-HETE in invertebrates is via lipoxygenation of arachidonic acid . In mammals, 12(R)-HETE can be produced by 12(R)-LOs and also by CYP450 oxidation. The activity of 12(R)-HETE in mammals is predominantly proinflammatory. 12(R)-HETE exhibits dose-dependent leukocyte chemotaxis at concentrations as low as 100 nM, and lowers intraocular pressure in rabbits.
T60350	Apraclonidine
	Apraclonidine (ALO 2145) 是一种选择性α2和弱 α1 受体激动剂，可有效降低人眼的眼内压。Apraclonidine 也是一种局部滴眼液。
T70735	Verosudil hydrochloride
	Verosudil, also known as AR-12286, is a potent and selective Rho kinase inhibitor. AR-12286 was well tolerated and provided statistically significant reduction in IOP (intraocular pressure) in patients with XFS (exfoliation syndrome) and OHT (ocular hypertension) or XFG (exfoliative glaucoma). This drug may represent an additional therapeutic paradigm for the treatment of XFG.
T61180	GAT564
	GAT564 (Compound 15d) is a highly effective allosteric modulator of cannabinoid 1 receptor (CB1R), having EC50 values of 87 nM and 320 nM for cAMP and β-arrestin2, respectively. It significantly enhances the binding of orthosteric ligands to hCB1R. Moreover, GAT564 exhibits remarkable efficacy as a topical agent, resulting in a significant reduction of intraocular pressure (IOP) in an ocular normotensive murine model of glaucoma [1].
T62036	Sovesudil
	Sovesudil (PHP-201) 是有效的、ATP 竞争性局部作用 Rho 激酶(ROCK)抑制剂。Sovesudil 抑制 ROCK I 和 ROCK II 的IC50分别为 3.7 和 2.3 nM。Sovesudil 可以降低眼压而不引起充血。
T64241	Brinzolamide hydrochloride
	Brinzolamide (AL-4862) hydrochloride 是一种碳酸酐酶 II（carbonic anhydrase II）的选择性抑制剂 (IC50: 3.2 nM)。Brinzolamide hydrochloride 能够抑制睫状体 CA-II，减少房水分泌，进而降低眼压 (IOP)。Brinzolamide hydrochloride 能够用于研究青光眼疾病。
T16388	Omidenepag isopropyl	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration. Omidenepag isopropyl is a selective EP2 receptor agonist. Omidenepag isopropyl displays only a weak affinity for EP1, EP2, and FP receptors. Omidenepag isopropy
T63637	ROCK-IN-4
	ROCK-IN-4 是 ROCK 的有效抑制剂，可维持 NO 释放能力。ROCK-IN-4 能够可逆地解聚 F-肌动蛋白，并阻碍人小梁网 (HTM) 细胞的线粒体呼吸。ROCK-IN-4 能够用于研究青光眼或高眼压。
T74736	2MD
	2MD是一种口服活性维生素D类似物，能刺激骨膜骨形成并减少小梁骨吸收，从而恢复小梁和皮质骨的质量与强度。在非人灵长类动物研究中，2MD还可以调节(IOP)相关基因，降低眼压。
T73083	Nipradolol KT 210 ; K 351 ; Hypadil,Hypadil,KT 210,K 351
	Nipradolol (KT-210; K-351) 是一种有效的 α-1-肾上腺素能受体的阻滞剂。Nipradolol 还抑制白化兔模型中 Phenylephrine 诱导的眼压升高 (IOP)。Nipradolol 抑制去甲肾上腺素 (NA) 引起的肌肉收缩，对犬冠状动脉也有血管扩张剂活性。
T37935	16-phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide 16-phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide
	The actions of many clinical F-series prostaglandins (PGs), including those used for estrous synchronization and for reduction of intraocular pressure (IOP), are mediated through the PGF2α (FP) receptor. 16-phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide (16-phenoxy tetranor PGF2α cyclopropyl methyl amide) is an analog of PGF2α containing a 16-phenoxy group on the lower (ω) side chain and a cyclopropyl methyl amide at the C-1 position. There are no published reports on the biological...
T36908	Bimatoprost grenod 15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α
	Bimatoprost grenod(15-(6-nitroxyhexanoyl)-17-phenyl trinor PGF2α) is a nitric oxide-donating derivative of 17-phenyl trinor PGF2α.1It increases cGMP levels in rabbit aqueous humor and iris ciliary body when topically administered at a concentration of 0.042%. Topical administration of 15-(6-nitroxylhexanoyl)-17-phenyl trinor PGF2α(0.14%) reduces intraocular hypertension (IOP) in a rabbit model of hypertonic saline-induced transient ocular pressure. It also reduces IOP in a cynomolgus monkey mode...
T38113	AL 6598
	Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins such as PGF2α and PGD2, have been shown to reduce IOP. AL 6598 is the isopropyl ester prodrug of AL 6556, a PGD2 receptor agonist that binds to DP receptors with a Ki value of 3.2 μM and demonstrates an EC50 value of 0.80 μM in an in vitro functional assay. Designed to enhance corneal absorption, AL 6598 produces a maximum 53% drop in IOP of the ocular hypertensive monkey with a 1 μg do...
T37941	17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide 17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide
	Prostaglandin F2α (PGF2α) activates the FP receptor, promoting smooth muscle contraction and luteolysis. 17-phenyl trinor PGF2α binds the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α. It is produced in vivo by the hydrolysis of 17-phenyl trinor PGF2α ethyl amide. 17-phenyl trinor PGF2α ethyl amide is used to reduce intraocular pressure related to glaucoma. 17-phenyl trinor PGF2α cyclopropyl methyl amide is a lipophilic analog of 17-phenyl trinor PGF...
T71119	Netarsudil free base
	Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. Netarsudi...
T36059	Dichlorphenamide-13C6 Dichlorphenamide-13C6
	Dichlorphenamide-13C6is intended for use as an internal standard for the quantification of dichlorphenamide by GC- or LC-MS. Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively).1It lowers intraocular pressure in rabbits when 50 μl of a 10% solution is applied topically to the eye.2Dichlorphenamide rescues the potassium deficiency and prevents insulin-induc...
T70186	Methazolamide-d6
	Methazolamide-d6 is intended for use as an internal standard for the quantification of methazolamide by GC- or LC-MS. Methazolamide is a carbonic anhydrase inhibitor. It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. Methazolamide reduces electroshock-induced seizures in rats with an ED50 value of 19.2 mg/kg. It also inhibits production of reactive oxygen species (ROS) in a primary cortical neuron (PCN) cellular model of subarachnoid hemorrhage (SAH) and re...
T37933	15-keto Latanoprost (free acid)
	15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals. 15-keto Latanoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Although much less potent that the parent compound latanoprost, 15-keto latanoprost still retains the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 μg/eye. 15-keto Latanoprost is al...
T38204	GAT229
	GAT229 is a positive allosteric modulator of cannabinoid receptor 1 (CB1) and the S-(-) enantiomer of the CB1 modulator GAT211. It does not activate the receptor on its own but enhances the binding and activity of CB agonists. GAT229 (1 μM) enhances the binding of the CB1 full agonist CP 55,940 to CHO cells expressing human recombinant CB1 (hCB1), as well as the activity of 2-arachidonoyl glycerol , arachidonoyl ethanolamide , and CP 55,940 in arrestin2 recruitment assays and increases ERK1/2 an...

化合物

Cat.No: T3174

Synonym: CP-544326

Target: Prostaglandin Receptor

Cat.No: T12670

Synonym: MGV354,外消旋MGV354

Target: Others

Cat.No: T0142

Synonym: 布林佐胺,AL-4862

Target: Carbonic Anhydrase

Cat.No: T0106

Synonym: L584601,醋甲唑胺,CL 8490

Target: Carbonic Anhydrase

Cat.No: T60924

Synonym: AR-12286

Target: ROCK

Brimonidine Tartrate

Cat.No: T6422

Synonym: AGN190342 tartrate,304 tartrate,酒石酸溴莫尼定,AGN190342 (tartrate),UK 14304 (tartrate),UK14304 tartrate

Target: Adrenergic Receptor

Cat.No: T19870

Synonym: 3-Acetoxyquinuclidine,1-azabicyclo[2.2.2]octan-3-yl acetate,NSC657843,3-quinuclidinyl acetate,NSC-657843,Glaucostat,NSC 657843,Quinuclidin-3-yl acetate

Target: AChR

Netarsudil Dihydrochloride

Cat.No: T10358

Synonym: AR-13324 Dihydrochloride

Target: ROCK

Apraclonidine hydrochloride

Cat.No: T21371

Synonym: Iopidine,ALO 2145,Apraclonidina,P-aminoclonidine,4-Aminoclonidine,Apraclonidine HCl,Apraclonidinum

Target: Adrenergic Receptor

Latanoprostene bunod

Cat.No: T15719

Synonym: LBN,NCX116

Target: Others

Cat.No: T22029

Target: 5-HT Receptor, Adrenergic Receptor

Bromfenac sodium hydrate

Cat.No: T2403

Synonym: Bromfenac sodium,Bromfenac monosodium salt sesquihydrate,溴芬酸钠

Target: COX

H-0106 Dihydrochloride

Cat.No: T25483

Synonym: H 0106 2HCl,H0106 2HCl,H0106 Dihydrochloride

Cat.No: T13955

Target: Others

H-0104 Dihydrochloride

Cat.No: T25482

Synonym: H0104 Dihydrochloride,H0104 2HCl,H 0104 Dihydrochloride,H 0104 2HCl,H-0104 2HCl

Netarsudil mesylate

Cat.No: T10358L2

Synonym: AR-13324 (mesylate)

Target: Others

Cat.No: T19682

Synonym: (S)-(-)-Betaxolol,(S)-Betaxolol

Latanoprost lactone diol

Cat.No: T11821

Target: Others

Nabitan hydrochloride

Cat.No: T28126

Synonym: Benzopyranoperidine,A-40656,A40656,SP-106,A 40656,Nabutam

Cat.No: T71120

Cat.No: T60807

15-keto Prostaglandin F2α

Cat.No: T37991

Synonym: 15-keto Prostaglandin F2α,15-keto PGF2α

Target: Endogenous Metabolite, Prostaglandin Receptor

Dichlorphenamide disodium

Cat.No: T61216

Prostaglandin F2α isopropyl ester

Cat.No: T38196

Synonym: Prostaglandin F2α isopropyl ester

Cat.No: T75155

Prostaglandin F2α methyl ester

Cat.No: T38198

AR-13324 analog mesylate

Cat.No: T10357

Target: Others

Carbonic anhydrase inhibitor 3

Cat.No: T60848

Carbonic anhydrase inhibitor 2

Cat.No: T61120

Tafluprost ethyl amide

Cat.No: T37956

Prostaglandin E3

Cat.No: T38194

Synonym: PGE3

Cat.No: T36145

Cat.No: T60350

Verosudil hydrochloride

Cat.No: T70735

Cat.No: T61180

Cat.No: T62036

Brinzolamide hydrochloride

Cat.No: T64241

Omidenepag isopropyl

Cat.No: T16388

Target: Prostaglandin Receptor

Cat.No: T63637

Cat.No: T74736

Cat.No: T73083

Synonym: KT 210 ; K 351 ; Hypadil,Hypadil,KT 210,K 351

16-phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide

Cat.No: T37935

Synonym: 16-phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide

Bimatoprost grenod

Cat.No: T36908

Synonym: 15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α

Cat.No: T38113

17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide

Cat.No: T37941

Synonym: 17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide

Netarsudil free base

Cat.No: T71119

Dichlorphenamide-13C6

Cat.No: T36059

Synonym: Dichlorphenamide-13C6

Methazolamide-d6

Cat.No: T70186

15-keto Latanoprost (free acid)

Cat.No: T37933

Cat.No: T38204

Cat. No.	Product Name	Target	Signaling Pathways
T1071L	DL-Adrenaline Hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	DL-Adrenaline Hydrochloride 是天然存在的拟交感神经胺的盐酸盐，具有收缩血管、降低眼内压的活性。

天然产物

DL-Adrenaline Hydrochloride

Cat.No: T1071L

Target: Adrenergic Receptor

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